Representative publications

Mechanisms for disease

Probabilistic fine-mapping of transcriptome-wide association studies. Mancuso N, Freund MK, Johnson R, Shi H, Kichaev G, Gusev A, Pasaniuc B. Nature Genetics. 2019 Apr; 51(4):675-682. doi: 10.1038/s41588-019-0367-1

Transcriptome-wide association study identifies new prostate cancer susceptibility genes in the OncoArray data. Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, the PRACTICAL consortium, CRUK, BPC, CAPS, PEGASUS, Kote-Jarai Z, Eeles R, Freedman M, Haiman C, Pasaniuc B. Nature Communications. 2018 Oct 4;9(1):4079. doi: 10.1038/s41467-018-06302-1

Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits. Mancuso N, Shi H, Goddard P, Kichaev G, Gusev A†, Pasaniuc B†. American Journal of Human Genetics. 2017 Mar 2;100(3):473-487. doi: 10.1016/j.ajhg.2017.01.031

Genetic architecture and selection

The contribution of rare variation to prostate cancer heritability. Mancuso N†, Rohland N†, Rand K, Tandon A, Allen A, Quinque D, Mallick S, Li H, Stram A, Sheng X, Kote-Jarai Z, Easton DF, Eeles RA, the PRACTICAL consortium, Le Marchand L, Lubwama A, Stram D, Watya S, Conti D, Henderson B, Pasaniuc B, Haiman C, Reich D. Nature Genetics. 2016 Jan;48(1):30-5. doi: 10.1038/ng.3446

† indicates equal contribution

preprints

All Publications

Find us on Google, Pubmed or DBLP. † indicates equal contribution

2019

  1. Genetic control of gene expression and splicing in the developing human brain. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. Cell (in press)

  2. Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture. Hou K†, Burch KS†, Majumdar A, Shi H, Mancuso N, Wu Y, Sankararaman S, Pasaniuc B. Nature Genetics (in press)

  3. Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI.
    Major M, Freund MK, Burch KS, Mancuso N, Ng M, Furniss D, Pasaniuc B†, Ophoff R†. Genetic Epidemiology. 13 May 2019. https://doi.org/10.1002/gepi.22209

  4. Probabilistic fine-mapping of transcriptome-wide association studies. Mancuso N, Freund MK, Johnson R, Shi H, Kichaev G, Gusev A, Pasaniuc B. Nature Genetics. 2019 Apr; 51(4):675-682. doi: 10.1038/s41588-019-0367

  5. Opportunities and challenges for transcriptome-wide association studies. Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles D, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Bjorkegren JLM†, Im HK†, Pasaniuc B†, Rivas MA†, Kundaje A†. Nature Genetics. 2019 Apr;51(4):592-599. doi: 10.1038/s41588-019-0385-z. Epub 2019 Mar 29. PMID: 30926968 

  6. Genome-wide meta-analysis of gene-environmental interaction for insulin-resistance phenotypes and breast cancer risk in postmenopausal women. Jung, SY, Mancuso, N, Yu, H, Papp, J, Sobel, EM, Zhang, ZF. Cancer Prevention Research. 2019 Jan;12(1):31-42. doi: 10.1158/1940-6207.CAPR-18-0180

2018

  1. Transcriptome-wide association study identifies new prostate cancer susceptibility genes in the OncoArray data. Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, the PRACTICAL consortium, CRUK, BPC, CAPS, PEGASUS, Kote-Jarai Z, Eeles R, Freedman M, Haiman C, Pasaniuc B. Nature Communications. 2018 Oct 4;9(1):4079. doi: 10.1038/s41467-018-06302-1

  2. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Gusev A, Mancuso N, Won H, Finucane HK, Reshef Y, Song L, Safi A, Oh E, Schizophrenia Working Group of the Psychiatric Genomics Consortium, McCarroll S, Neale B, Ophoff R, O’Donovan MC, Katsanis N, Geschwind DH, Crawford GE, Sullivan PF, Pasaniuc B† and Price AL†. Nature Genetics. 2018. Apr;50(4):538-548. doi: 10.1038/s41588-018-0092-1

  3. Appetite, cachexia regulator, and placental gene GDF15 associated with nausea and vomiting of pregnancy and hyperemesis gravidarum. Fejzo MS, Sazonova OV Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM. Nature Communications. 2018 Mar 21;9(1):1178. doi: 10.1038/s41467-018-03258-0

2017

  1. Targeted mutagenesis in a human-parasitic nematode. Gang SS, Castelletto ML, Bryant AS, Yang E, Mancuso N, Lopez JB, Pellegrini M, Hallem EA. PLOS Pathogens. 2017 Oct 10;13(10):e1006675. doi: 10.1371/journal.ppat.1006675

  2. Local genetic correlation gives insights into the shared genetic architecture of complex traits. Shi H, Mancuso N, Spendlove S, and Pasaniuc B. American Journal of Human Genetics. 2017 Nov 2;101(5):737-751. doi: 10.1016/j.ajhg.2017.09.022

  3. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hellwege JN, Jeff JM, Wise LA, Gallaghe CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR. Human Genetics. 2017 Oct;136(10):1363-1373. doi: 10.1007/s00439-017-1836-1

  4. Enhanced methods to detect haplotypic effects on gene expression. Brown R, Kichaev G, Mancuso N, Boocock J, Pasaniuc B. Bioinformatics. 2017 Aug 1;33(15):2307-2313. doi: 10.1093/bioinformatics/btx142

  5. Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits. Mancuso N, Shi H, Goddard P, Kichaev G, Gusev A†, Pasaniuc B†. American Journal of Human Genetics. 2017 Mar 2;100(3):473-487. doi: 10.1016/j.ajhg.2017.01.031

2016

  1. The contribution of rare variation to prostate cancer heritability. Mancuso N†, Rohland N†, Rand K, Tandon A, Allen A, Quinque D, Mallick S, Li H, Stram A, Sheng X, Kote-Jarai Z, Easton DF, Eeles RA, the PRACTICAL consortium, Le Marchand L, Lubwama A, Stram D, Watya S, Conti D, Henderson B, Pasaniuc B, Haiman C, Reich D. Nature Genetics. 2016 Jan;48(1):30-5. doi: 10.1038/ng.3446

2014

  1. Accurate viral population assembly from ultra-deep sequencing data. Mangul S, Wu NC, Mancuso N, Zelikovsky A, Sun R, Eskin E. Bioinformatics. 2014 Jun 15;30(12):i329-37. doi: 10.1093/bioinformatics/btu295

2013

  1. Reconstruction of Viral Population Structure from Next-Generation Sequencing Data Using Multicommodity Flows. Skums P†, Mancuso N†, Artyomenko A†, Tork B, Măndoiu I, Khudyakov Y, and Zelikovsky A. BMC Bioinformatics. 2013; 14(Suppl 9): S2. doi: 10.1186/1471-2105-14-S9-S2

2012

  1. Reconstructing Viral Quasispecies from NGS Amplicon Reads. Mancuso N, Tork B, Skums P, Ganova-Raeva L, Măndoiu I, and Zelikovsky A, In Silico Biology. 2011-2012;11(5-6):237-49. doi: 10.3233/ISB-2012-0458

  2. EDR2: A Sink Failure Resilient Approach for WSNs. Valero M, Xu M, Mancuso N, Song W, and Beyah R. Conf Proc IEEE International Conference on Communications (ICC). 2012. DOI: 10.1109/ICC.2012.6363781

The banner image shows the San Gabriel mountains covered in snow during Winter 2019. Photo taken near Big Pines.